马春红（1970.11--），博士  山东大学医学院免疫学研究所教授、博士生导师，山东大学医学院副院长。第八届霍英东基金会高等院校青年教师基金获得者，2009年度教育部入选“新世纪优秀人才支持计划”，山东省杰出青年基金获得者，山东省优秀博士论文(2010)、山东省优秀硕士论文(2008)指导教师。中华医学会微生物与免疫学分会青年委员会委员、山东免疫学会常务理事。

【主要学历】

    1987.9~1991.7  山东师范大学生物系，理学学士

1991.9~1994.7  华中师范大学生物系，理学硕士

1999.7~2002.7  山东大学免疫学研究所，博士学位。

【工作经历】

1994.7毕业分配至原山东医科大学微生物与免疫学教研室，助教、讲师。 2000年度被评为山东医科大学十佳青年。2001年1月破格晋升为副教授。2003年获第八届霍英东基金会高等院校青年教师基金。2003年被评为山东大学医学院优秀青年教师，并荣获山东大学优秀青年教师能手称号，同年，破格晋升为正教授。2004.2-2005.2 美国肯塔基大学免疫学、微生物学与分子遗传学系访问学者。2006年6月被聘为博士生导师，2006年被评为山东省第三批中青年科技人才。2009年入选教育部“新世纪优秀人才支持计划”，同年获山东省第二届杰出青年基金资助。

【科研兴趣与科研工作】

主要针对严重危害我国人民健康的HBV相关肝病，重点研究HBV与宿主相互作用，从HBV及其编码蛋白对宿主免疫和宿主生长相关关键基因的调控两个方面，研究HBV相关肝病发生的关键机制，以期为HBV相关肝病防治提供新靶点。以通讯作者在Gastroenterology、Gut、J Hepatology、J Cell Mol Med等杂志发表SCI收录论文多篇。

【代表性论文】*通讯作者，** 并列通讯作者

1.         Zhuang X, Zhang X, Xia X, Zhang C, Liang X, Gao L, Zhang X, Ma C.* Ectopic Expression of TIM-3 in Lung Cancers. Am J Clin Pathol. 2012 Jun;137(6):978-85.

2.         Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y, Ma C.* Zinc Fingers and Homeoboxes 2 Inhibits Cell Proliferation and Represses Cyclin A and Cyclin E expression. Gastroenterology. 2012 Jun;142(7):1559-1570.e2. Epub 2012 Mar 6.

3.         Hou N, Zhao D, Liu Y, Gao L, Liang X, Liu X, Gai X, Zhang X, Zhu F, Ni M, Zhang Y, Sun W, Ma C. *. Augmented expression of T cell immunoglobulin- and mucin-domain-containing molecule-3 on NK cells in atherogenesis. Atherosclerosis. 2012 May;222(1):67-73. Epub 2012 Feb 13.

4.         Zhao D, Hou N, Cui M, Liu Y, Liang X, Zhuang X, Zhang Y, Zhang L, Yin D, Gao L, Zhang Y, Ma C*. Increased T cell Immunoglobulin and Mucin Domain 3 Positively Correlate with Systemic IL-17 and TNF-α Level in the Acute Phase of Ischemic Stroke. J Clin Immunol. 2011 Aug;31(4):719-27. Epub 2011 Apr 26.

5.         Peterson ML, Ma C, Spear BT.Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer. Semin Cancer Biol. 2011 Feb; 21(1):21-7. Epub 2011 Jan 7.

6.         Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, Liu Y, Zhu F, Zhang L, Sun W, Liang X, Gao L, Ma C*, T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B.J Hepatol. 52 (2010) pp.322-329；2010 Jan 6. [Epub ahead of print]

7.         Luan F, Liu H, Gao L, Liu J, Sun Z, Ju Y, Hou N, Guo C, Liang X, Zhang L, Sun W, Ma C. *，Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT. Gut. 2009 Nov;58(11):1528-37. Epub 2009 Aug 2.

8.         Ju Y, Hou N, Zhang XN, Zhao D, Liu Y, Wang JJ, Luan F, Shi W, Zhu FL, Sun WS, Zhang LN, Gao CJ, Gao LF, Liang XH, Ma CH.* Blockade of Tim-3 Pathway Ameliorates Interferon-gamma Production from Hepatic CD8(+) T Cells in a Mouse Model of Hepatitis B Virus Infection. Cell Mol Immunol. 2009 Feb;6(1):35-43.

9.         Shen H, Luan F, Liu H, Gao L, Liang X, Zhang L, Sun W, Ma C*.ZHX2 is a Repressor of Alpha-fetoprotein Expression in Human Hepatoma Cell Lines. J Cell Mol Med. 2008 Dec; 12(6B):2772-80.

10.     Liu Y, Shu Q, Gao L, Hou N, Zhao D, Liu X, Zhang X, Xu L, Yue X, Zhu F, Guo C, Liang X, Ma C*.  Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity. Clin Immunol. 2010 Nov;137(2):288-95.

11.     Zhao D, Hou N, Cui M, Liu Y, Liang X, Zhuang X, Zhang Y, Zhang L, Yin D, Gao L, Zhang Y, Ma C*. Increased T cell Immunoglobulin and Mucin Domain 3 Positively Correlate with Systemic IL-17 and TNF-α Level in the Acute Phase of Ischemic Stroke. J Clin Immunol. 2011 Aug;31(4):719-27.

12.     Peterson ML, Ma C, Spear BT.Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer. Semin Cancer Biol. 2011 Feb; 21(1):21-7.

13.     Liu H, Shi W, Luan F, Xu S, Yang F, Sun W, Liu J, Ma C.*., Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. Virus Genes. 2010 Apr;40(2):174-82. Zhao P, Xu L, Wang P, Liang X, Qi J, Liu P, Guo C, Zhang L, Ma C, Gao L. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus. Cell Mol Immunol. 2010 Mar;7(2):152-6.

14.     Wang Y, Meng J, Wang X, Liu S, Shu Q, Gao L, Ju Y, Zhang L, Sun W, Ma C*.Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients. Scand J Immunol. 2008 Jan;67(1):63-70