姓名:                            高远生

任职：                          北京大学医学部生理学与病理生理学系教授，博士生导师

通讯地址：                    北京市海淀区学院路38号 生理学与病理生理学系

邮编：                          100191

电话:                            011-86-10-82805038

E-Mail:                           ygao@bjmu.edu.cn

研究领域：  气管平滑肌收缩与舒张的调节（1986-1992）；血管平滑肌舒张机制（1992--现在）。目前研究课题：1）血管反应调节的一氧化氮-可溶性鸟苷酸环化酶-环鸟苷酸蛋白激酶机制；2）血管反应的氧化还原调节机制。

 近5年代表性论文:

1.        Qi H, Zheng X, Qin X, Dou D, Xu H, Raj JU, Gao Y. PKG regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br J Pharmacol, 152: 1060-1069, 2007.

2.        Dou D, Zheng X, Qin X, Qi H, Liu L, Raj JU, Gao Y. Role of PKG in development of nitroglycerin tolerance of porcine coronary arteries. Br J Pharmacol, 153: 497-507, 2008.

3.        Dou D, Ma H, Zheng X, Ying L, Guo Y, Yu X, Gao Y. Degradation of leucine zipper positive isoform of MYPT1 may contribute to development of nitrate tolerance. Cardiovasc Res, 86:151-159, 2010. 

4.        Ma H, He Q, Dou D, Zheng X, Ying L, Wu Y, Raj JU, Gao Y. Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery. Am J Physiol Lung Cell Mol Physiol, 299: L117-L123, 2010.

5.        Gao Y, Raj JU. Regulation of the pulmonary circulation in the fetus and newborn. Physiol Rev 90:1291-1335, 2010.

6.        Gao Y. The multiple actions of NO. Pflügers Archiv - Eur J Physiol, 459: 829-839, 2010.

7.        Zheng X, Ying L, Liu J, Dou D, He Q, Leung SWS, Man RYK, Vanhoutte PM, Gao Y. Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide. Cardiovas Res, 90: 565-572, 2011.

8.        Ying L, Xu X, Liu J, Dou D, Yu X, Ye L, He Q, Gao Y. Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: Role of PKG and MYPT1. Pflügers Archiv - Eur J Physiol, 463: 257-268, 2012.

9.         Xu X, Wang S, Liu J,Dou D, Liu L, Chen Z, Ye L, Liu H, He Q, Raj JU, Gao Y. Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p. J Cell Sci; Advance Online Publication October 4, 2012, doi:10.1242/jcs.113381.

10.    Ye L, Liu J, Liu H, Ying L, Dou D, Chen Z, Xu X, Raj JU, Gao Y. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates relaxation of porcine pulmonary vessels to nitric oxide. Pflügers Archiv - Eur J Physiol, Online First™, 9 November 2012.