讲师北京大学医学部基础医学院
教师简介

张艳,女, 1993年至1997年就读于华东理工大学生物化学专业,获理学学士学位。1999年至2002年就读于北京市创伤骨科研究所,攻读免疫化学专业,获硕士学位。2002年至2005年就读于北京大学,攻读病理生理学专业,获医学博士学位。2005年至2010年在北京大学医学部生理学与病理生理学系任讲师职务。主要科研方向为移植颌下腺分泌调控机制的研究。2010年至2012年在美国国立卫生院牙科及颌面外科研究所访问。2012年10月至今在北京大学医学部生理学与病理生理学系任讲师职务。目前主持一项国家自然基金(TRPV4调控颌下腺水和电解质分泌的分子机制, 81170974)。代表性研究论文有:

1. Zhang Y, Catalán MA, Melvin JE. TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation. Am J Physiol Gastrointest Liver Physiol. 2012 Oct 18.

2. Ding Q, Zhang Y, Cong X, Cai Z, Han J, Su Y, Wu LL, Yu GY. Confocal microscopy with double immunofluorescence staining reveals the functional transient receptor potential vanilloid subtype 1 expressed in myoepithelial cells of human submandibular glands. Microsc Res Tech. 2012 75(5):555-60.

3. Cong X*, Zhang Y*, Shi L, Yang NY, Ding C, Li J, Ding QW, Su YC, Xiang RL, Wu LL, Yu GY. Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland. Lab Invest. 2012 92(5):753-68.

4. Yang NY, Shi L, Zhang Y, Ding C, Cong X, Fu FY, Wu LL, Yu GY. Ischemic preconditioning reduces transplanted submandibular gland injury. J Surg Res. 2012

5. Catalán MA, Flores CA, González-Begne M, Zhang Y, Sepúlveda FV, Melvin JE. Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels. Gastroenterology. 2012 142(2):346-54.

6.Ding C, Zhang Y, Peng X, Wang Y, Zhang L, Cong X, Ding QW, Xiang RL, Wu LL, and Yu GY. Proteomic Analysis of Human Transplanted Submandibular Gland in Patients with Epiphora after Transplantation.Journal of Proteome Research. 10:2206-15, 2011.

7. Zhang Y*, Cong X*, Shi L, Xiang B, Li YM, Ding QW, Ding C, Wu LL and Yu GY. Activation of transient receptor potential vanilloid subtype 1 increases secretion of the hypofunctional, transplanted submandibular gland. Am J Physiol Gastrointest Liver Physiol 299: G54–G62, 2010.

8. Shi L, Cong X, Zhang Y, Ding C, Ding QW, Fu FY, Wu LL and Yu GY. Carbachol improves secretion in the early phase after rabbit submandibular gland transplantation. Oral Diseases 2010; 16: 351–359.

9. Q Ding W, Zhang Y, Wang Y, Wang YN, Zhang L, Ding C, Wu LL *, and Yu GY * Functional Vanilloid Receptor-1 in Human Submandibular Gland. J. Dent Res. 2010 89:711-716.

10. Li YM*, Zhang Y*, Shi L, Xiang B, Cong X, Zhang YY, Wu LL and Yu GY. Isoproterenol Improves Secretion of Transplanted Submandibular Glands. J Dent Res 2009; 88: 477-482.

11. Xiang B, Zhang Y, Li YM, Gao Y, Gan YH, Wu LL, Yu GY. Phenylephrine protects autotransplanted rabbit submandibular gland from apoptosis. Biochem Biophys Res Commun 2008; 377: 210–214.

12. Zhang Y, Xiang B, Li YM, Wang Y, Wang X, Wang YN, Wu LL, Yu GY. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland. Biochem Biophysic Res Commun, 2006; 345:467-473.

13. Li YM, Zhang Y, Xiang B, Zhang YY, Wu LL, Yu GY. Expression and functional analysis of beta-adrenoceptor subtypes in rabbit submandibular gland. Life Science, 2006; 9:2091-2098.

14. Xiang B, Zhang Y, Li YM, Zhang YY, Wu LL, YU GY. Effect of phenylephrine on transplanted submandibular gland. J Dent Res 2006; 85:1106-1111.