1998 南开大学 学士 2001 南开大学 硕士 2006 美国佛罗里达大学 博士 2006--2009 美国德克萨斯大学M.D.安德森癌症研究中心 博士后 2009--2011 美国哈佛大学医学院布雷根及妇女医院 博士后 2011-- 南开大学生命科学学院 教授 研究方向 ■ 致病菌毒性基因的表达调控及作用机制; ■ 宿主在感染过程中的免疫反应 发表文章: ■ Wu W, Huang J, Duan B, Traficante DC, Hong H, Risech M, Lory S, Priebe GP. (2012) Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia. Am. J. Respir. Crit. Care Med. Sep 1;186(5):420-7. (IF=10) ■ Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 285(34):25969-77. ■ Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14. (IF=25) ■ Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. (2008) MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31.. ■ Yang, H., Z. Shan, J. Kim, W. Wu, W. Lian, L. Zeng, L. Xing and S. Jin. (2007) Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa. J Bacteriol. 189(7):2599-609 ■ Wu, W., Y. Song, S. Jin and S. Chen. (2006) An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10. ■ Jyot, J., A. Sonawane, W. Wu and R. Ramphal. (2007) Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38. ■ Wu, W. and S. Jin. (2005) PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68.(IF=4) ■ Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. (2004) MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85.(IF=4)