许凤荣 理学硕士，药物化学系讲师
办公电话: 82801558　　电子邮箱: xfr0331@163.com

个人简历
1990-1993 北京大学药学院硕士

1993-1994 北京医科大学药学院药物化学系助教

1994-至今 北京大学医学部药化系讲师 

主讲课程

主讲本科、夜本《药物化学》、《药物化学实验》

研究方向

1.Mek抑制剂的合成；

2.抗老年痴呆药物b-分泌酶抑制剂的设计、合成；

获得奖励
2007药学院青年教师讲课技能选拔赛第二名

北京大学教学成果一等奖（创新人才培养与药物化学课程改革  2010）

2010北京大学医学部教学成果一等奖 

2012年北京大学教育教学成果一等奖

2012年北京大学医学部教育教学成果一等奖

北京大学实验技术成果二等奖（药物化学实验教学改革 2012）

2013年北京大学医学部教学优秀个人奖

近五年代表性论文

(1) YongJian Li, FengRong Xu, Yan Niu, XiaoMin Zou, Yue Yuan, HaiFei Gao, Chao Wang, GuanYu Yang, Qi Sun, Ping Xu*. Efficient synthesis of terminal α,β-unsaturated ketones as the intermediates of the proteasome epoxyketone inhibitors via Weinreb amide. Journal of Chinese Pharmaceutical Sciences. 2011, 20: 564-71.

(2) Hai-Fei Gao, Yan Niu*, Feng-Rong Xu, Lei Liang, Bo Zhou, Yong-Jian Li, Chao Wang, Peng Liu, Ping Xu*, Design and synthesis of benzimidamides as potential BACE1 inhibitors, Journal of Chinese Pharmaceutical Sciences, 2012, 21(2):124-131.

(3) Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang  and Ping Xu,* The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies, Chem Biol Drug Des, 2012, 79: 972-80.

(4) Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors; Chem Biol Drug Des, 2012, 80: 775-780 .

(5) Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors; Letters in Drug Design & Discovery, 2013, 10 (4): 297-302.

(6)Liang, L.; Yang, G.; Wang, W.; Xu, F.; Niu, Y.; Sun, Q.; Xu, P*.A Copper-Catalyzed Aerobic Cascade Dehydrogenative-Dehalogenative Reaction, Advanced Synthesis & Catalysis, 2013,355 (7): 1284-1290.

(7) Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun and Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation; Org. Lett. 2013, 15 (11), 2770–2773.

(8) Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents, Molecules 2013, 18, 6057-6091.

(9)  Chao Wang, Fengrong Xu*, Yan Niu*, Yun Wu, Jing Sun, Yihong Peng, Lei Liang, Ping Xu*, Synthesis and Biological Evaluations of 3-Benzothiazol-2-yl Coumarin Derivatives as MEK1 Inhibitors, Letters in Drug Design & Discovery,2013, 10(8): 727-732.