教授华中科技大学公共卫生学院
教师简介

王爱国,男,医学博士,教授,博士生导师,教育部新世纪优秀人才,现任劳动卫生与环境卫生学系副主任,主持环境卫生学的教学工作。1987年毕业于湖南医科大学卫生系,1992年在原同济医科大学获硕士学位,1999年在德国Ulm大学获博士学位。兼任中华医学会地方病学分会委员、中国地方病学杂志编委等。自参加工作以来一直从事环境卫生学的教学和科研工作,承担本科生《环境卫生学》和《预防医学》等必修课以及《环境优生学》、《微量元素与健康》、《环境污染与公共卫生事件》等选修课的教学工作。主要研究方向为环境重要化学污染物的毒作用机制及其健康危害。主持和参加包括国家自然科学基金重大、重点和面上项目、973国家重点基础研究规划项目和国家科技攻关计划在内的科学研究工作。以第一作者或通讯作者发表科研论文60余篇,其中分别在Toxicol Sci、Neurotoxicology、Toxicol Lett和Mutat Res等国外杂志上发表SCI收录论文20余篇,是Toxicol Sci、Toxicology、Toxicol Lett、Nurotoxicology等国际杂志的审稿人。2011年获教育部高等学校科学研究优秀成果奖自然科学二等奖(第一完成人)。参编全国高等学校教材《生物材料检验》(副主编)、教育部面向21世纪课程教材《微量元素与健康》(副主编)、全国高等学校教材《环境卫生学》(第7版,编委)、环境卫生学大型参考书《现代环境卫生学》(第2版,编委兼学术秘书)等多部教材。
已发表的主要学术论文(*通讯作者):
1. Ping Gao, Ping He, Aiguo Wang*, Tao Xia, BaYi Xu, ZhiXia Xu, Qiang Niu, LiJuan Guo, XueMin Chen. Influence of PCB153 on oxidative DNA damage and DNA repair-related gene expression induced by PBDE-47 in human neuroblastoma cells in vitro. Toxicol Sci. 2009, 107(1):165-70.
2. Ping He, Weihong He, Aiguo Wang*, Tao Xia, Bayi Xu, Ming Zhang, Xuemin Chen. PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology. 2008, 29(1):124-129.
3. Ping He, Aiguo Wang*, Tao Xia, Ping Gao, Qiang Niu, Lijuan Guo, Xuemin Chen. Mechanisms of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicology. 2009, 30(1):10-15.
4. Ping He, Aiguo Wang*, Tao Xia, Ping Gao, Qiang Niu, Lijuan Guo, Xuemin Chen. Mechanisms underlying the developmental neurotoxic effect of PBDE-47 and the enhanced toxicity associated with its combination with PCB153 in rats. Neurotoxicology. 2009, 30(6):1088-95.
5. Ming Zhang, Aiguo Wang*, Tao Xia, Ping He. Effects of fluoride on DNA damage, S-phase cell-cycle arrest and the expression of NF-kappaB in primary cultured rat hippocampal neurons. Toxicol Lett. 2008, 179(1):1-5.
6. Aiguo Wang*, Qilong Chu, Weihong He, Tao. Xia, Junling Liu, Ming Zhang, Andreas Nussler, Xuemin Chen, Kide Yang. Effects on protein and mRNA expression levels of p53 induced by fluoride in human embryonic hepatocytes. Toxicol Lett. 2005, 158(2):158-163.
7. Chunyang Jiang, Shun Zhang, HongLiang Liu, Qiang Zeng, Tao Xia, Yihu Chen, Gang Kuang, Guodong Zhao, Xue Wu, Xiaofei Zhang, Aiguo Wang*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro. Toxicol Lett. 2012, 211(3):325-33.
8. Ming Zhang, Aiguo Wang*, Weihong He, Ping He, Bayi Xu, Tao Xia, Xuemin Chen, Kedi Yang. Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons. Toxicology. 2007, 236(3):208-216.
9. Weihong He, Ping He, Aiguo Wang*, Tao Xia, Bayi Xu, Xuemin Chen. Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutat Res. 2008, 649(1-2):62-70.
10. Aiguo Wang*, Tao Xia, Jing Yuan, Rian Yu, Kedi Yang, Xuemin Chen, Wei Qu, M.P.Waalkes. Effects of phenobarbital on metabolism and toxicity of diclofenac sodium in rat hepatocytes in vitro. Food and Chem Toxicol, 2004, 42(10):1647-53.
11. Xianzhi Xiong, Aiguo Wang, Guohong Liu, Hongkai Liu, Chong Wang, Tao Xia, Xuemin Chen, Kedi Yang. Effects of p,p’-dichlorodiphenyldichoroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells. Environ Res. 2006,
12. Xianzhi Xiong, Junling Liu, Weihong He, Tao Xia, Ping He, Xuemin Chen, Kedi Yang, Aiguo Wang*. Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children. Environ Res. 2007, 103(1):112-116.
13. Junling Liu, Tao Xia, Ming Zhang, Weihong He, Ping He, Xuemin Chen, Kedi Yang, Aiguo Wang*. Screening of environmental response genes related to dental fluorosis. Fluoride. 2006, 39(3):195-201.
14. Aiguo Wang*, Tao Xia, Rian Ru, Xuemin Chen, KediYang. Antagonistic effects of selenium on oxidative stress, DNA damage, and apoptosis induced by fluoride in human hepatocytes. Fluoride. 2004, 37(2):107-16.
15. Weihong He, Aiguo Wang*, Tao Xia, Ping Gao, Bayi Xu, Zhixia Xu, Ping He, Xuemin Chen. Cytogenotoxicity induced by PBDE-47 combined with PCB153 treatment in SH-SY5Y cells. Environ Toxicol. 2010, 25(6):564-572.
16. Bayi Xu, Zhixia Xu, Tao Xia, Ping He, Ping Gao, Weihong He, Ming Zhang, Lijuan Guo, Qiang Niu, Aiguo Wang*. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells. Environ Toxicol. 2011, 26(1):86-92.
17. Ping He, Aiguo Wang*, Qiang Niu, Lijuan Guo, Tao Xia, Xuemin Chen. Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats. Toxicol Ind Health. 2011, 27(3):279-88.
18. Qiang Niu, HongLiang Liu, ZhiZhong Guan, Qiang Zeng, ShuXia Guo, Ping He, LiJuan Guo, Ping Gao, BaYi Xu, ZhiXia Xu, Tao Xia, Aiguo Wang*. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells. Biol Trace Elem Res. 2012, 149(1):102-9.
19. Aiguo Wang*, Tao Xia, Qilong Chu, Ming Zhang, Fang Liu, Xuemin Chen, and Kedi Yang. Effects of fluoride on peroxidation, DNA damage and apoptosis in human embryo hepatocytes. Biomed Environ Sci. 2004, 17:217-22.
20. Aiguo Wang, Xuemin Chen. China should increase fundamental research on environmental health. Environ Health Perspect. 2009, 117(5):188.