副教授浙江大学基础医学系
教师简介

 

学习和工作经历

1999-2002 浙江大学医学院生理学,博士研究生
2003-2009 浙江大学医学院生理学,副教授
2009-至今 浙江大学医学院病理生理学,副教授

 

研究方向
1. 心脏移植的临床前研究
2. 脓毒症心血管损伤机制和治疗的研究

 

近5年科研资助
1. 线粒体乙醛脱氢酶2对脓毒症心肌的保护作用及其机制研究,国家自然科学基金项目(81272067),2013.1-2016.12
2. 葡萄糖加重脂多糖诱导的血管内皮炎症反应及其机制研究,浙江省自然科学基金项目(Y2100082),2011.1-2013.12
3. 葛根素对糖尿病血管内皮内质网应激的作用及机制研究  浙江省教育厅科研项目(Y200908945),2009.12-2011.12
4. 环氧化酶2抑制剂对抗心肌氧化应激的机制研究 国家自然科学基金项目(30400094)2005.1-2007.12

发表著作
1.高级病理生理学知识进展及其应用,浙江大学出版社,2012.2,主编,ISBN(书号):978-7-308-09500-6

近5年发表的主要论文
1.Xu HJ, Chen WL, Wang Y, Zheng MZ, Chen YY, Shen YL. S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 2012, 31(6):663-669
2. Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol  2012, 26(3):322-331
3. Yang F, Chen WL, Zheng MZ, Yu GW, Xu HJ, Shen YL, Chen YY. Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of bid in hypothermic preservation rat hearts. J Heart Lung Transplant 2011; 30(8): 928-34
4. Chen YY, Zheng MZ, Lv PP, Hu L, Wang LL, Shen YL. Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism. J Biochem Mol Toxicol 2010;24(5):279-285.
5. Meng XH, Ni C, Zhu L, Shen YL, Wang LL, Chen YY. Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta. Vascul Pharmacol. 2009, 50(3-4): 110-115.
6. Fang XD, Yang F, Zhu L, Shen YL,Wang LL, Chen YY. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clinical and Experimental Pharmacology and Physiology. 2009, 36(12): 1177-1182.
7. Chen N, Shao W, Lv PP, Zhang SL, Chen YY, Zhu L, Lu Y, Shen YL. Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells. Free Radical Research. 2007, 41(9):990-6