姓名：张晓东  电话：027-68756606  email: zhangxd@whu.edu.cn
职　　称：教授
学科专业： 细胞生物学
研究方向： 肿瘤分子生物学

教育经历：
1991-1995 武汉大学生命科学学院 学士
1995-1998 武汉大学生命科学学院 硕士
1998-2000 中国医学科学院基础医学研究所 博士
2004-2005 Georgetown University 博士后

工作经历
2000-2004中国医学科学院基础医学研究所 助理研究员，副研究员
2005-2008 Case Western Reserve University 研究助理
2008-至今 武汉大学生命科学学院教授

目前主要研究领域和兴趣：
　　本实验室以体细胞基因敲除/敲入技术为主要研究方法，从分子水平探讨肿瘤的发病机理, 研究相关基因作用途径和寻找理想的分子靶标，为肿瘤的早期诊断、治疗和预后提供理论依据。

代表性论文
[1] Zhang,X., Guo,C., Chen,Y., Shulha,H.P., Schnetz,M.P., LaFramboise,T., Bartels,C.F., Markowitz,S., Weng,Z., Scacheri,P.C., and Wang,Z. (2008). Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies. Nat. Methods 5, 163-165. （IF=15.478）

[2] Zhang,X., Guo,A., Yu,J., Possemato,A., Chen,Y., Zheng,W., Polakiewicz,R.D., Kinzler,K.W., Vogelstein,B., Velculescu,V.E., and Wang,Z.J. (2007). Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc. Natl. Acad. Sci. U. S. A 104, 4060-4064. （IF=9.643）

[3] Guo,C., Zhang,X., Fink,S.P., Platzer,P., Wilson,K., Willson,J.K., Wang,Z., and Markowitz,S.D. (2008). Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. Cancer Res. 68, 6118-6126. （IF=7.672）

[4] Zhang,X., Liu,H., Zhang,Y., Qiao,Y., Miao,S., Wang,L., Zhang,J., Zong,S., and Koide,S.S. (2003). A novel gene, RSD-3/HSD-3.1, encodes a meiotic-related protein expressed in rat and human testis. J. Mol. Med. 81, 380-387. （IF=5.157）

[5] Zhang,X.D., Miao,S.Y., Wang,L.F., Li,Y., Zong,S.D., Yan,Y.C., and Koide,S.S. (2000). Human sperm membrane protein (hSMP-1): a developmental testis-specific component during germ cell differentiation. Arch. Androl 45, 239-246. （IF=0.808）

[6] Ma PC, Zhang X, Wang ZJ. High-throughput mutational analysis of the human cancer genome. Pharmacogenomics. 2006 Jun; 7(4):597-612. (IF: 3.603)

[7] Zhuang D, Qiao Y, Zhang X, Miao S, Koide SS, Wang L. YWK-II protein/APLP2 in mouse gametes: potential role in fertilization. Mol Reprod Dev. 2006 Jan; 73(1):61-7. (IF: 2.379)

[8] He Z, Feng L, Zhang X, Geng Y, Parodi DA, Suarez-Quian C, Dym M. Expression of Col1a1, Col1a2 and procollagen I in germ cells of immature and adult mouse testis. Reproduction. 2005 Sep;130(3):333-41. (IF: 2.958)

[9] Liang G, Zhang XD, Wang LJ, Sha YS, Zhang JC, Miao SY, Zong SD, Wang LF, Koide SS. Identification of differentially expressed genes of primary spermatocyte against round spermatid isolated from human testis using the laser capture microdissection technique. Cell Res. 2004 Dec; 14(6):507-12. (IF: 3.426)

[10] Shengwei Zou, Jianchao Zhang, Xiaodong Zhang, Shiying Miao, Shudong Zong, Qi Sheng, Linfang Wang.Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. Cell Reserch 2003; 13(3) ：171-177. (IF: 3.426)